This 1-hour course reviews practical principles for safe systemic prescribing in primary eye care. Emphasis is placed on medication history and risk assessment; pregnancy, lactation, pediatric, geriatric, renal, and hepatic considerations; weight-based pediatric dose calculation; and appropriate use of commonly prescribed oral antiviral and antibacterial agents. Clinical applications include herpes simplex keratitis, herpes zoster ophthalmicus, eyelid and periocular infection, adult inclusion conjunctivitis, chronic lid disease, and recurrent corneal erosion.