This lecture advances the optometric surgeon from foundational cryosurgical principles to clinical application in periocular and adnexal disease. Emphasis is placed on patient selection, lesion assessment, technique selection, dosing strategies, complication avoidance, and postoperative management. Learners will integrate cryobiologic theory with real-world procedural decision-making to achieve safe, effective, and cosmetically acceptable outcomes while recognizing limitations, contraindications, and medico-legal considerations of cryosurgery in optometric practice.