This lecture builds on foundational knowledge to help optometrists interpret complex dermatopathology reports of periocular and facial skin lesions. It focuses on recognizing malignant and premalignant entities such as squamous cell carcinoma, basal cell carcinoma and subtypes, and benign mimickers. Key histologic patterns are reviewed and correlated with clinical behavior through case-based images, emphasizing accurate risk assessment, timely referral, and a safety-driven approach beyond clinical appearance alone.