Traditional pharmaceutical and surgical glaucoma treatment drawbacks led to the arrival of Minimally Invasive Glaucoma Surgeries (MIGS). Due to an excellent safety profile coupled with at worst modest efficacy, MIGS has been labeled one of the bigger breakthroughs in glaucoma treatment. Mastering MIGS starts with understanding the mechanisms of action for aqueous outflow including, trabecular meshwork (TM)/Schlemm’s canal, suprachoroidal space, and finally subconjunctival outflow. Combination MIGs and stand-alone MIGs will be discussed.