Coastal shelf regions are experiencing more frequent and widespread hypoxia events, which represent an acute stress on ecosystem health and resiliency.  Such events are fundamentally connected to eutrophication. However, aspects of the coupled physical-biogeochemical processes at play can vary by region and location. Here, hypoxia in the Mississippi Bight during summer of 2025 is investigated to better understand the mechanisms driving this regional phenomena. Time series data from a long-term mooring site reveal low dissolved oxygen conditions began as early as April with intermittent occurrences of hypoxia throughout the summer.  Hydrographic surveys over a portion of the shelf were consistent with the time series data and showed that these low dissolved oxygen conditions were wide-spread. The early onset of hypoxia over the shelf was correlated with very high levels of local river discharge suggesting regional dissolved oxygen conditions are likely impacted by both Mississippi River water (i.e., remote source) as well as local watersheds (i.e., local sources). The hydrographic structure of the water column and the associated water flow velocity suggest that the relative contribution of these source waters may depend on physical transport and mixing events.  The results of this study are expected to facilitate the development of more effective mitigation and adaptation strategies in response to current and predicted changes in coastal oceans.