Climate change is posing a severe threat to the Gulf of Mexico, impacting fish populations and distributions, shifting ecosystems, and altering large scale ocean and atmospheric circulation patterns. Although climate vulnerability assessments are performed on popular Gulf of Mexico species, these assessments are based on expert opinion rather than quantitative figures. Therefore, a spatial-temporal ecosystem model is needed to quantitatively assess how ocean productivity will change in the near to long-term future. This study uses a spatially explicit model of the Gulf of Mexico large marine ecosystem and overlays spatial-temporal climate drivers with fishing scenarios using the Ecopath with Ecosim (EwE) and Ecospace software. EwE is a modeling framework that incorporates bottom-up changes in productivity, trophic interactions, and habitat structure with spatial and temporal dynamics to predict impacts of environmental conditions, management, and policy changes on marine ecosystems. Alternative climate and fishing scenarios are to be run through the Gulf-wide ecosystem model (GWEM) with climate spatial temporal drivers- from NOAA’s Modular Ocean Model 6- overlain. Ultimately, this project aims to build a climate-informed assessment tool that will support decision-makers in the Gulf of Mexico and inform climate adaptive fisheries beyond. The synthesis of climate and species interactions will yield information on potential winners and losers, biomass and mortality projections, and distribution maps. This tool will enhance our ability to forecast future ecosystem changes and propose adaptive management strategies that can safeguard both the economic and ecological future of the Gulf of Mexico’s fisheries.