Federal and State trustees evaluate impacts from releases of hazardous substances and/or oil into the environment to evaluate potential natural resource damage assessments (NRDAs). Addressing data gaps about exposures to multiple contaminants and incorporating that knowledge into new and existing conceptual model(s) will benefit the NRDA decision-making process. Bottlenose dolphins (Tursiops truncatus) in the Houston area/Galveston Bay are exposed to dioxins, polychlorinated biphenyls (PCBs), and other contaminants and are the focus of this RESTORE project. This 5-year project will: 1) Analyze blubber samples from new and archived samples to determine the concentrations of PCBs and dioxins; 2) Conduct bi-annual photo-ID surveys of bottlenose dolphins and use spatial capture-recapture to determine survival rates in Galveston Bay and compare those to other southeast US populations; 3) analyze remote biopsy skin samples for epigenetic markers to gain an understanding of age and health of sampled dolphins; 4) use lab exposures of cell lines to determine dose-response relations of PCBs, dioxins, and relevant mixtures of PCBs and dioxins. This talk will provide updates on progress to date: field work, including completed photo-ID and remote biopsy sampling; stakeholder engagement, both completed and planned; chemical analyses; and plans for the cell line study and epigenetic work. We are eager to receive feedback on this project from GulfCon attendees.  The final results of the project will be co-produced statistical models, conceptual models, and analyses that will be used Galveston Bay but will also useful for other locations. At the conclusion of the project, decision makers will have these models, methods, and information to design more targeted studies for specific cases and assessments.