This year marks 10 years since designation of the Mississippi Based RESTORE Act Center of Excellence (MBRACE) through the Centers of Excellence Research Grants Program in accordance with the RESTORE ACT. Over the past decade, MBRACE has made substantial investments in research to further the understanding of oyster reef sustainability and water quality in Mississippi and better inform state-led resource and restoration mangers. These investments are through MBRACE’s Core Research Program, a long-term initiative to build on and expand monitoring, modeling, and mapping in the Mississippi Sound, and its Competitive  Grants Program, where data and modeling complements work being completed through the Core Research Program. The structure of these funding programs lends itself to the development of large, synthetic outputs. In an effort to maximize the usability and impact of data collected over the past 10 years, MBRACE is undergoing an effort to synthesize data collected since its designation. Here, we share our framework, synthesis process and how these synthetic outputs can and are being used to advance the state of the knowledge for oyster reef sustainability and water quality in the northern Gulf.