Hurricane Milton made landfall as a Category 3 storm on October 9, 2024, displacing hundreds of vessels that posed pollution risks to Gulf waters. As part of the response, the U.S. Coast Guard (USCG) operationalized integration of small Unmanned Aerial Systems (UAS) with RPI’s Vessel All-hazards Debris Response (VADR) application (included in NOAA’s response toolkit). A fourteen-person USCG Port Assessment Team employed Parrot ANAFI USA and Skydio X2D drones under pre-existing FAA emergency authorization, conducting 72 missions totaling 112 flight hours between October 10-28. The team assessed 652 pollution-threat vessels across 72 square nautical miles encompassing Port of Tampa Bay and Port Manatee facilities generating $42 billion annually and supporting 234,000 jobs. The integrated UAS-VADR workflow transformed aerial imagery into georeferenced pollution assessments with risk scores, enabling prioritized contractor removal operations. The response achieved 100% target assessment in 19 days, facilitating removal of 1,460 gallons of oil and hazardous substances at a cost of $500,000 while preventing an estimated 1.2-1.5 million gallons from entering Gulf waters. Cost-effectiveness ratios of $342 per gallon removed and $0.33-$0.42 per gallon prevented represent one of the most efficient post-storm pollution responses in recent history. Operations overcame communications blackouts using Starlink and maintained 24/7 tempo with portable generators. Both ports reopened on schedule, and ten federal pollution cases were initiated. This response yielded a replicable "Milton Package" requiring minimal investment: two thermal/zoom sUAS, one Starlink terminal, VADR-trained personnel, pre-season FAA authorization, and annual exercises. This shows that commercially available drones paired with decision-support applications serve as the primary operational engine for maritime disaster response, shifting remote sensing from analysis to actionable intelligence.